[Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [99mTc]-TRODAT-1 and SPECT in Brazil].

Autor:	Shih MC; Laboratório Interdiciplinar de Neuroimagem e Cognição, Universidade Federal de São Paulo, and Departamento de Imagem, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. mingchi@psiquiatria.epm.br, Amaro E Jr, Ferraz HB, Hoexter MQ, Goulart FO, Wagner J, Lin LF, Fu YK, Mari JJ, de Lacerda AL, Tufik S, Bressan RA
Jazyk:	portugalština
Zdroj:	Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2006 Sep; Vol. 64 (3A), pp. 628-34.
DOI:	10.1590/s0004-282x2006000400021
Abstrakt:	Background: Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss in vivo in Parkinsons disease (PD). Objective: To evaluate DAT density in vivo using [99mTc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD. Method: Fifteen PD patients and 15 matched healthy controls scanned with [99mTc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales. Results: PD patients had significantly lower striatal DAT-BP (mean+/-SD) (0.38+/-0.12) compared to controls (BP=0.84+/-0.16; p<0.01). A 100% sensitivity and 100% specificity was obtained to discriminate PD cases from controls. Negative correlations between striatal DAT-BP and PD severity (rho=-0.7, p<0.001) and motor scales (rho=-0.80, p<0.001) were found. Conclusion: [99mTc]TRODAT-1 SPECTs scanning was able to discriminate PD patients from controls. The technique is a powerful instrument to measure DAT density that can be used in clinical and research settings in Brazil.
Databáze:	MEDLINE
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