Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor.

Autor:	Constantine JW; Exploratory Medicinal Chemistry, Pfizer Central Research, Pfizer Inc., Groton, CT 06340., Lebel WS, Woody HA
Jazyk:	angličtina
Zdroj:	Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 1990 Dec; Vol. 342 (6), pp. 722-4.
DOI:	10.1007/BF00175719
Abstrakt:	Neurokinin A, neurokinin B and substance P caused concentration-related contractions of rabbit isolated aorta with pD2 values of 8.1, 6.9, and 6.0, respectively. [D-Pro2, D-Trp7, 9]-substance P, a competitive tachykinin antagonist, had pA2 values of 5.3 against neurokinin A, 5.1 against neurokinin B and 5.2 against substance P indicating that tachykinin receptors mediated responses to the agonists. [pGlu5,MePhe8,-MeGly9]-substance P 5 - 11 (DiMe-C7), senktide and septide did not contract the aorta. It is concluded that of the known tachykinin receptors smooth muscle of the rabbit isolated aorta contains only the NK-2 type.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink