| Autor: |
Gomis R; Endocrinology and Diabetes Unit, Hospital Clínic Universitari, IDIBAPS, Barcelona University, Barcelona, Spain. rgomis@clinic.ub.es, Storms F, Conget I, Sinnassamy P, Davies M |
| Jazyk: |
angličtina |
| Zdroj: |
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2007 Jul; Vol. 77 (1), pp. 84-91. Date of Electronic Publication: 2006 Nov 09. |
| DOI: |
10.1016/j.diabres.2006.10.002 |
| Abstrakt: |
This study assessed the incidence of severe hypoglycaemia with two insulin glargine titration algorithms: Algorithm 1 (increments of at least 10%, but not exceeding 4U) versus Algorithm 2 (1-6U increments). In this multicenter (n=409), multinational (n=54), open-label, 24-week randomized trial in 2442 subjects with sub-optimally controlled Type 1 diabetes (T1DM), mean prior insulin therapy duration was 14.6+/-10.3 years. The incidence of severe hypoglycaemia was similar with Algorithms 1 and 2 (16.6events/100 patient-years versus 14.4events/100 patient-years). There were similar rates of both symptomatic and nocturnal hypoglycaemia. HbA(1c) and fasting blood glucose (FBG) decreased significantly (baseline to endpoint; p<0.001), and comparably with Algorithms 1 and 2 (HbA(1c): -0.64% versus -0.72%; FBG: -57mg/dL versus -59mg/dL). Mean basal insulin dose increased with both algorithms (+5.7U versus +5.9U). In a diverse population with longstanding T1DM, transfer from any insulin regimen, including basal-bolus or premixed insulin to an insulin glargine-based regimen resulted in significant improvements in glycaemic control, with low rates of severe hypoglycaemia, irrespective of the titration algorithm used. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect