Use of a gestational carrier for a patient with recurrent adverse pregnancy outcomes from early onset severe pre-eclampsia.
| Autor: | Farley DM; Department of Obstetrics and Gynecology, University of Kansas School of Medicine-Wichita, Wichita, Kansas 67226, USA., Grainger DA, Tjaden BL, Frazier LM, Maki JE |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Fertility and sterility [Fertil Steril] 2007 Jan; Vol. 87 (1), pp. 189.e1-3. Date of Electronic Publication: 2006 Nov 02. |
| DOI: | 10.1016/j.fertnstert.2006.04.050 |
| Abstrakt: | Objective: To describe the first reported case of gestational carrier treatment to prevent severe early onset pre-eclampsia. Design: Case report. Setting: A university-based reproductive endocrinology and infertility clinic and a tertiary care hospital. Patient(s): A 29-year-old woman and her husband with three consecutive pregnancies complicated by early onset severe pre-eclampsia causing fetal demises at 22 and 24 weeks gestation; a neonatal death at 25 weeks gestation; and life-threatening maternal hemolysis, elevated liver enzymes, and low platelets. Intervention(s): An IVF procedure in the patient using her husband's sperm with the transfer of two embryos to a friend who offered to be a gestational carrier. Main Outcome Measure(s): Successful IVF cycle in the patient and uncomplicated pregnancy and delivery in the gestational carrier. Result(s): The gestational carrier achieved a pregnancy and progressed without complications to delivery of a healthy, 3.2-kg infant at 39 weeks gestation. Conclusion(s): The use of a gestational carrier deserves consideration as a treatment option in patients with poor reproductive histories because of early onset severe pre-eclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. This experience also suggests that development of pre-eclampsia may be in large part maternally rather than embryologically or paternally driven. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|