| Autor: |
Gosso MF; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands. mf.gosso@vumc.nl, van Belzen M, de Geus EJ, Polderman JC, Heutink P, Boomsma DI, Posthuma D |
| Jazyk: |
angličtina |
| Zdroj: |
Genes, brain, and behavior [Genes Brain Behav] 2006 Nov; Vol. 5 (8), pp. 577-84. |
| DOI: |
10.1111/j.1601-183X.2006.00211.x |
| Abstrakt: |
The CHRM2 gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, we genotyped three single-nucleotide polymorphisms (SNPs) in the CHRM2 gene on 7q31-35. From all individuals, standardized intelligence measures were available. Using a test of within-family association, which controls for the possible effects of population stratification, a highly significant association was found between the CHRM2 gene and intelligence. The strongest association was between rs324650 and performance IQ (PIQ), where the T allele was associated with an increase of 4.6 PIQ points. In parallel with a large family-based association, we observed an attenuated - although still significant - population-based association, illustrating that population stratification may decrease our chances of detecting allele-trait associations. Such a mechanism has been predicted earlier, and this article is one of the first to empirically show that family-based association methods are not only needed to guard against false positives, but are also invaluable in guarding against false negatives. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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