| Autor: |
Shcherbakov AM; N. N. Blokhin Russian Cancer Research Center, Moscow. cesaro@front.ru, Lobanova YS, Shatskaya VA, Onopchenko OV, Gaspar'yan AV, Gershtein ES, Krasil'nikov MA |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2006 Mar; Vol. 141 (3), pp. 357-60. |
| DOI: |
10.1007/s10517-006-0170-8 |
| Abstrakt: |
A new substrain of hormone-resistant MCF-7/T breast cancer cells was selected after long-term culturing of estrogen-dependent MCF-7 cells in the presence of tamoxifen. These cells were resistant to the growth-stimulating and cytostatic effects of estradiol and tamoxifen, respectively. MCF-7/T cells gained paradoxical sensitivity to the apoptotic effect of estradiol. Estradiol stimulated p53 expression and decreased DNA-binding activity of NF-kappaB. Our findings provide indirect evidence that these proteins are involved in the regulation of estrogen-induced apoptosis. These results indicate that tamoxifen-resistant breast cancer cells can be sensitized to the apoptotic effect of estradiol. The data form a basis for the development of new methods of endocrine therapy for breast cancer patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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