Growth hormone is a stimulating but not an essential factor in healing of colon. A study in GH-deficient dwarf rats.

Autor:	Tei TM; Department of Surgery L, University Hospital of Aarhus, Medical Research Lab M., Aarhus, Denmark. tei@dadlnet.dk, Kissmeyer-Nielsen P, Flyvbjerg A, Christensen H
Jazyk:	angličtina
Zdroj:	Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society [Scand J Surg] 2006; Vol. 95 (3), pp. 205-10.
DOI:	10.1177/145749690609500315
Abstrakt:	Background: Growth hormone (GH) has been implicated as an important factor in the healing and previous studies showed significant strength acceleration of experimental intestinal anastomoses. Aim: To study the healing of experimental colonic anastomoses in GH-deficient rats and to study the potential physiological effects of GH-substitution on healing parameters. Conclusion: Exogenous rhGH treatment started 7 days prior to surgery and continued until day 4 postoperatively accelerates the strength development of the experimental colonic anastomoses in dwarf rats indicating a potent role of growth hormone in colonic healing. However, GH is not essential in the healing process, since anastomotic healing in GH-deficient dwarf rats is like rats with normal pituitary function.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu