Matching of the minor histocompatibility antigen HLA-A1/H-Y may improve prognosis in corneal transplantation.
| Autor: | Böhringer D; Eye Hospital and LIONS Cornea Bank Regio/Baden-Württemberg, University Hospital Freiburg, Germany. daniel.boehringer@uniklinik-freiburg.de, Spierings E, Enczmann J, Böhringer S, Sundmacher R, Goulmy E, Reinhard T |
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| Jazyk: | angličtina |
| Zdroj: | Transplantation [Transplantation] 2006 Oct 27; Vol. 82 (8), pp. 1037-41. |
| DOI: | 10.1097/01.tp.0000235908.54766.44 |
| Abstrakt: | Background: Minor histocompatibility (H) antigens are peptides of allelic intracellular proteins that play an important role in human leukocyte antigen (HLA) matched transplantations. In an animal model of keratoplasty, minor H antigens have even been reported to exceed the immunogenicity of major H antigens (MHC). This investigation is to assess any benefit of matching the broadly expressed gender (H-Y) and HA-3 antigens in HLA-A1 donor positive human keratoplasty. Methods: A total of 229 HLA-A1 donor positive keratoplasties were analyzed. A Cox proportional hazards model and Kaplan-Meier analysis were applied to estimate the effect of H-Y or HA-3 mismatches on rejection-free graft survival. Results: Eighty-one cases were mismatched for H-Y (male donor to female recipient). A mean follow up of two years showed graft survival as high as 88% in the H-Y compatible group compared to only 77% in the H-Y mismatched group (P = 0.02). Eight out of 62 cases were mismatched for HA-3. No statistically significant influence of HA-3 matching on rejection-free graft survival was observed (85% vs. 73%, P=0.52). Conclusion: HLA-A1/H-Y matching and matching for other broadly expressed minor H antigens may further improve prognosis in keratoplasty. |
| Databáze: | MEDLINE |
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