| Autor: |
McCluskie MJ; Coley Pharmaceutical Group, Inc., 93 Worcester Street, Suite 101, Wellesley, MA 02481, USA., Krieg AM |
| Jazyk: |
angličtina |
| Zdroj: |
Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2006; Vol. 311, pp. 155-78. |
| DOI: |
10.1007/3-540-32636-7_6 |
| Abstrakt: |
The adaptive immune system-with its remarkable ability to generate antigen-specific antibodies and T lymphocytes against pathogens never before "seen" by an organism-is one of the marvels of evolution. However, to generate these responses, the adaptive immune system requires activation by the innate immune system. Toll-like receptors (TLRs) are perhaps the best-understood family of innate immune receptors for detecting infections and stimulating adaptive immune responses. TLR9 appears to have evolved to recognize infections by a subtle structural difference between eukaryotic and prokaryotic/viral DNA; only the former frequently methylates CpG dinucleotides. Used as vaccine adjuvants, synthetic oligodeoxynucleotide (ODN) ligands for TLR9--CpG ODN--greatly enhance the speed and strength of the immune responses to vaccination. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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