| Autor: |
Mancini I; Laboratorio di Chimica Bioorganica, Dipartimento di Fisica, Università di Trento, I-38050 Povo-Trento, Italy. mancini@science.unit.it, Guella G, Frostin M, Hnawia E, Laurent D, Debitus C, Pietra F |
| Jazyk: |
angličtina |
| Zdroj: |
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2006 Dec 04; Vol. 12 (35), pp. 8989-94. |
| DOI: |
10.1002/chem.200600783 |
| Abstrakt: |
Reported here is the first polyarsenic compound ever found in nature. Denominated arsenicin A, it was isolated along a bioassay-guided fractionation of the organic extract of the poecilosclerid sponge Echinochalina bargibanti collected from the north-eastern coast of New Caledonia. In defining an adamantine-type polyarsenic structure for this compound, deceptively simple NMR spectra were complemented by extensive mass spectral analysis. However, it was only the synthesis of a model compound that provided the basis to discriminate structure 4 from other spectrally compatible structures for arsenicin A; to this end, a comparative ab initio simulation of IR spectra for the natural and the synthetic compounds was decisive. Arsenicin A is endowed with potent bactericidal and fungicidal activities on human pathogenic strains. All this may revive pharmacological interest in arsenic compounds while prompting us to rethink the arsenic cycle in nature. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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