Occurrence of nervous system involvement in SIRS.

Autor: Marchiori PE; Department of Neurology, Hospital das Clínicas, Sao Paulo University School of Medicine, São Paulo, Brazil. marchiori@hcnet.usp.br, Lino AM, Hirata MT, Carvalho NB, Brotto MW, Scaff M
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2006 Dec 01; Vol. 250 (1-2), pp. 147-52. Date of Electronic Publication: 2006 Oct 09.
DOI: 10.1016/j.jns.2006.08.015
Abstrakt: Systemic inflammatory response syndrome (SIRS) is a medical condition in which the all-organ microcirculation is affected including nervous system. We describe neurological findings in 64 patients with SIRS at Hospital das Clínicas of Sao Paulo University School of Medicine; 45.3% were male and 54.7% female; their age ranged from 16 to 95 years old. SIRS was caused by infection in 68.8% of patients, trauma in 10.9%, burns in 7.8%, and elective surgery in 4.7%. The central nervous system involvement occurred in 56.3% of patients and was characterized as encephalopathy in 75%, seizures in 13.9%, non-epileptic myoclonus in 2.8%, and ischemic stroke in 8.3%. The magnetic resonance imaging, cerebrospinal fluid and electroencephalographic changes were unremarkable in encephalopathic patients. Neuromuscular disorders were diagnosed in 43.7%. Critical ill polyneuropathy was characterized in 57.1%, critical ill myopathy in 32.1%, demyelinating neuropathy in 7.2%, and pure motor neuropathy in 3.6%. Nerve and muscle pathological studies dismissed inflammatory abnormalities. The identification of these conditions has important economic implications and may change the critically ill patients' prognosis.
Databáze: MEDLINE
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