Nucleotide sequence of the Yersinia pestis gene encoding F1 antigen and the primary structure of the protein. Putative T and B cell epitopes.

Autor: Galyov EE; Institute of Immunology, USSR Ministry of Medical Industry, Lyubuchany, Moscow Region., Smirnov OYu, Karlishev AV, Volkovoy KI, Denesyuk AI, Nazimov IV, Rubtsov KS, Abramov VM, Dalvadyanz SM, Zav'yalov VP
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 1990 Dec 17; Vol. 277 (1-2), pp. 230-2.
DOI: 10.1016/0014-5793(90)80852-a
Abstrakt: The plasmid-located gene caf1 encoding the capsular antigen fraction 1 (F1) of Yersinia pestis was cloned and sequenced. The gene codes for a 170 amino acid peptide with a deduced Mr of 17.6 kDa. The signal peptide sequence was highly homologous to the E. coli consensus signal sequence. The F1 was assumed to have beta-sheet structure for the most part. The region located between amino acids 100 and 150 was suggested to contain putative antigenic determinants and to stimulate T cells.
Databáze: MEDLINE