Ocular toxicity related to cetuximab monotherapy in patients with colorectal cancer.

Autor: Dranko S; University of Pittsburgh Cancer Institute, PA, USA., Kinney C, Ramanathan RK
Jazyk: angličtina
Zdroj: Clinical colorectal cancer [Clin Colorectal Cancer] 2006 Sep; Vol. 6 (3), pp. 224-5.
DOI: 10.3816/CCC.2006.n.040
Abstrakt: Cetuximab is a monoclonal antibody that specifically blocks the epidermal growth factor receptor pathway. Cetuximab is now a standard drug to treat refractory advanced colorectal cancer. The most common side effect is a rash, seen in most patients. Ocular toxicity is uncommon. We report 2 cases of ocular toxicity characterized by blepharitis and conjunctivitis related to cetuximab administration. Strategies for management are discussed.
Databáze: MEDLINE