| Autor: |
Jin BF; Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing 100850, China., He K, Wang HX, Bai B, Zhou T, Li HY, Man JH, Liu BY, Gong WL, Wang J, Li AL, Zhang XM |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of proteome research [J Proteome Res] 2006 Oct; Vol. 5 (10), pp. 2815-23. |
| DOI: |
10.1021/pr060283f |
| Abstrakt: |
We implemented a proteomics approach to the systematical analysis of the alterations in the proteome of NIH3T3 cells transformed by oncogenic H-RasV12. Forty-four proteins associated with Ras-mediated transformation have been identified, and 28 proteins were not previously reported. RT-PCR analysis showed that approximately 44% of target proteins identified showed concomitant changes in mRNA abundance. A principal finding was the up-regulation of gankyrin, which was the first evidence to show that gankyrin pathway was implicated in Ras-activated transformation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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