| Autor: |
Schroeder CP; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA., Kadara H, Lotan D, Woo JK, Lee HY, Hong WK, Lotan R |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer research [Cancer Res] 2006 Oct 01; Vol. 66 (19), pp. 9762-70. |
| DOI: |
10.1158/0008-5472.CAN-05-4124 |
| Abstrakt: |
Celecoxib is being evaluated as a chemopreventive agent. However, its mechanism of action is not clear because high doses were used for in vitro studies to obtain antitumor effects. We found that celecoxib inhibited the growth of premalignant and malignant human bronchial epithelial cells with IC(50) values between 8.9 and 32.7 micromol/L, irrespective of cyclooxygenase-2 (COX-2) expression. Normal human bronchial epithelial cells were less sensitive to celecoxib. Because these concentrations were higher than those attainable in vivo (
|
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
