| Autor: |
Mousli M; Laboratoire de Neuroimmunopharmacologie, Université Louis Pasteur, Strasbourg I, France., Bronner C, Bockaert J, Rouot B, Landry Y |
| Jazyk: |
angličtina |
| Zdroj: |
Immunology letters [Immunol Lett] 1990 Sep; Vol. 25 (4), pp. 355-7. |
| DOI: |
10.1016/0165-2478(90)90207-7 |
| Abstrakt: |
Pretreatment of purified calf brain G proteins with activated pertussis toxin or antibodies raised against the C-terminus of their alpha subunits prevented the increase in GTPase activity induced by substance P, compound 48/80 and mastoparan. These results suggest that these mast cell secretagogues activate G proteins directly via an interaction with the C-terminus of alpha subunits of G proteins by mimicking the agonist-liganded receptors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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