| Autor: |
Rozeman LB; Department of Pathology, Leiden University Medical Center, RC Leiden, The Netherlands., Cleton-Jansen AM, Hogendoorn PC |
| Jazyk: |
angličtina |
| Zdroj: |
International orthopaedics [Int Orthop] 2006 Dec; Vol. 30 (6), pp. 437-44. Date of Electronic Publication: 2006 Aug 30. |
| DOI: |
10.1007/s00264-006-0212-x |
| Abstrakt: |
Bone- and cartilage-forming tumours (osteosarcomas and chondrosarcomas) are rare malignant neoplasms. These tumours are clinically aggressive and often need extensive local and/or systemic treatment. Whereas no other treatment but surgery is currently available for chondrosarcomas, osteosarcomas show an approximately 50-80% response rate to adjuvant chemotherapy. Surgical removal of these tumours is currently mostly performed with limb salvage, but amputation may be required in some cases. In addition, the tumours have a risk of local recurrences adversely affecting the prognosis compared to the primary tumour. In this report we will mainly focus on two of the most prevalent malignant bone tumours, conventional osteosarcoma and conventional chondrosarcoma, and use these to illustrate the problems with the diagnosis of bone sarcomas in general. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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