Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis.

Autor: Aghai ZH; Department of Pediatrics, Division of Neonatology, Cooper University Hospital-Robert Wood Johnson Medical School, One Cooper Plaza, Camden, NJ 08103, USA. aghai-zubair@cooperhealth.edu, Mudduluru M, Nakhla TA, Amendolia B, Longo D, Kemble N, Kaki S, Sutsko R, Saslow JG, Stahl GE
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2006 Sep; Vol. 26 (9), pp. 550-5.
DOI: 10.1038/sj.jp.7211570
Abstrakt: Background: Extremely low birth weight (ELBW) infants are at increased risk for invasive candidiasis and associated morbidity and mortality. The use of fluconazole prophylaxis in this population has raised a benefit versus risk concern among clinicians.
Objectives: To evaluate the effectiveness and safety of fluconazole prophylaxis in ELBW infants.
Study Design: ELBW infants (BWResults: Nine out of 137 infants (6.6%) developed invasive candidiasis during PPE compared to none of 140 (0%) during PE (P=0.006). During PE, 60/140 (42.9%) infants developed conjugated hyperbilirubinemia compared to 12/137 (8.8%) during PPE (P<0.001).
Conclusion: Although a fluconazole prophylaxis regimen for ELBW infants was effective in preventing invasive candidiasis, an increase in the incidence of conjugated hyperbilirubinemia was observed. Further studies are needed to evaluate the safety of fluconazole prophylaxis in this population.
Databáze: MEDLINE
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