| Autor: |
Sigdel TK; Department of Chemistry and Biochemistry, Miami University, 112 Hughes Hall, Oxford, OH 45056, USA., Cilliers R, Gursahaney PR, Thompson P, Easton JA, Crowder MW |
| Jazyk: |
angličtina |
| Zdroj: |
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2006 Oct; Vol. 19 (5), pp. 461-71. |
| DOI: |
10.1007/s10534-005-4962-5 |
| Abstrakt: |
The adaptive response of Escherichia coli cells to differing intracellular and extracellular Zn(II) concentrations was evaluated by two-dimensional gel electrophoresis and peptide identifications. Twenty-one Zn(II)-responsive proteins, which were previously not known to be associated with Zn(II), were identified. Most of the proteins were related to cellular metabolism and include membrane transporters and glycolytic and TCA-associated enzymes. The expression levels of no known Zn(II) transporters were identified with these studies. The results of these studies suggest a role of Zn(II) in the expression levels of several E. coli proteins, and the results are discussed in light of recent genomic profiling studies on the adaptive response of E. coli cells to stress by Zn(II) excess. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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