Bone marrow processing with a gravity sedimentation technique: experience of 13 cases.

Autor: Adorno G; Cattedra di Ematologia, II Università degli Studi di Roma, Italy., Tribalto M, Cantonetti M, di Toritto TC, Cudillo L, Dentamaro T, Iampieri MP, Lucanto E, Masi M, Riguzzi MC, et. al.
Jazyk: angličtina
Zdroj: Haematologica [Haematologica] 1990 Jan-Feb; Vol. 75 Suppl 1, pp. 48-50.
Abstrakt: The experience of 13 bone marrow processings is reported: 7 patients were affected by Acute Leukemias, 4 by Non Hodgkin's Lymphomas, 1 by Chronic Myelogenous Leukemia in complete remission after induction chemotherapy, 1 by Ewing's Sarcoma. Gravity sedimentation technique with 6% hydroxyethyl starch was used in all cases. A mean value of 0.754 x 10(8)/kg body weight mononuclear cells was harvested after sedimentation, with a mean recovery of 74.554%. Mean CFU-GM value was 0.543 x 10(4)/kg body weight. Only one evaluable patient, affected by ANLL, underwent Autologous Bone Marrow Transplantation and a full engraftment was noted on day +14. Results are discussed and further studies are proposed to clarify the relationship between the in vitro CFU-GM growth and the bone marrow engraftment.
Databáze: MEDLINE