| Autor: |
Silaeva SA, Khatsernova BIa, Golenchenko VA, Berchenko GN, Nikolaev AIa, Shekhter AB |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy meditsinskoi khimii [Vopr Med Khim] 1990 Jan-Feb; Vol. 36 (1), pp. 82-4. |
| Abstrakt: |
Effect of 4-methyl uracil on dynamics of morphological patterns and the rate of nucleic acids synthesis was studied in granulation tissue developed during healing of full-layer skin wounds. Application of ointment containing 4-methyl uracil onto the wounds exhibited an antiinflammatory efficiency and decreased accumulation of leukocytes in the wound. The drug shortened the mitotic cycle in dividing fibroblasts, as a result of which periods of DNA synthesis became more frequent exhibiting two days duration. The rate of RNA synthesis was increased 1.5-2-fold. Content of acid glycosaminoglycans and collagen was increased in intercellular space surrounding fibroblasts. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
