| Autor: |
Savarin CG; Department of Process Research, Merck Research Laboratories, Merck & Company, P.O. Box 2000, Rahway, NJ 07065, USA. cecile_savarin@merck.com, Boice GN, Murry JA, Corley E, DiMichele L, Hughes D |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2006 Aug 31; Vol. 8 (18), pp. 3903-6. |
| DOI: |
10.1021/ol061318k |
| Abstrakt: |
An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. The resulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at very low catalyst loading. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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