| Autor: |
Hokita S; Dept of Surgery, Imamura Hospital, Japan., Aikou T, Ishigami S, Miyazono F, Nakajo A, Uenosono Y, Hamanoue M, Aridome K, Natsugoe S |
| Jazyk: |
japonština |
| Zdroj: |
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2006 Jun; Vol. 33 Suppl 1, pp. 95-8. |
| Abstrakt: |
In the present article, we report the results of phase I/II combination chemotherapy study of biweekly paclitaxel and S-1 administration in patients with advanced gastric cancer. In the phase I study, we could determine the recommended dose for the phase II study with paclitaxel and S-1 to be 120 mg/m2 and 80 mg/m2, respectively. The side effect was not so severe. The overall response was 53%. In conclusion, biweekly paclitaxel and S-1 administration can be safely combined for the treatment of advanced gastric cancer. This combined therapy represents a novel and active treatment regimen with low toxicity and can be defined as safe and effective. Now we are analyzing the result of the phase II study. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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