| Autor: |
Cooke GS; Wellcome Trust Centre for Human Genetics, Churchill Hospital, University of Oxford, Oxford, United Kingdom, OX3 7BN. grahamc@well.ox.ac.uk, Tosh K, Ramaley PA, Kaleebu P, Zhuang J, Nakiyingi JS, Watera C, Gilks CF, French N, Whitworth JA, Hill AV |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of infectious diseases [J Infect Dis] 2006 Sep 01; Vol. 194 (5), pp. 666-9. Date of Electronic Publication: 2006 Jul 28. |
| DOI: |
10.1086/505875 |
| Abstrakt: |
We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P=.007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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