| Autor: |
Carroll RG; Department of Physiology, East Carolina University School of Medicine, Greenville, NC 27858-4354., Iams SG, Pryor WH Jr, Allison EJ Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Resuscitation [Resuscitation] 1990 Jan; Vol. 19 (1), pp. 41-52. |
| DOI: |
10.1016/0300-9572(90)90097-x |
| Abstrakt: |
The opening of voltage sensitive calcium channels is an important event in the progression of irreversible shock, allowing the entry of toxic amounts of calcium (Ca2+) into the cells. Because intracellular magnesium (Mg2+) can efflux through these same channels, changes in serum Mg2+ may reflect the patency of these channels. In this study, electrolytes and selected serum enzymes were monitored in chronically instrumented conscious dogs to follow the progression of shock following a fixed volume hemorrhage. Plasma enzymes indicative of liver damage were elevated only in the terminal phase of hemorrhagic decompensation. A significant increase in serum Mg2+ was evident 60 min following hemorrhage, even though arterial pressure was still recovering. Serum Mg2+ continued to rise throughout the recovery and decompensating phases of shock. Verapamil treatment, which increased survival time and survival rate, significantly attenuated the changes in serum Mg2+ which normally followed hemorrhage. These results indicate that serum Mg2+ may be a useful indicator of the severity and the progression of hemorrhagic shock. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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