| Autor: |
Zweers ML; Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology, Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands., Engbers GH, Grijpma DW, Feijen J |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2006 Sep 12; Vol. 114 (3), pp. 317-24. Date of Electronic Publication: 2006 Jun 02. |
| DOI: |
10.1016/j.jconrel.2006.05.021 |
| Abstrakt: |
Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly(dl-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method. A fast release of drug in PBS (pH 7.4) at 37 degrees C resulting in 100% release within 5 h was observed for both drugs. The rate of drug release was substantially reduced by treating the particles with gelatin or albumin after drug loading, resulting in a linear drug release in time. It was shown that the rate of drug release is related to the amount of protein associated with the nanoparticles. After gelatin treatment of drug-loaded nanoparticles, sustained release of dexamethasone for 17 days and of rapamycin for 50 days could be achieved. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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