| Autor: |
Pimenta FC; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil., Miyaji EN, Arêas AP, Oliveira ML, de Andrade AL, Ho PL, Hollingshead SK, Leite LC |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 2006 Aug; Vol. 74 (8), pp. 4939-44. |
| DOI: |
10.1128/IAI.00134-06 |
| Abstrakt: |
One of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniae is PsaA (pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible alterations in the normal microbiota, especially in the case of PsaA, which was shown to have homologs with elevated sequence identity in other viridans group streptococci. In this work, we demonstrate that intranasal immunization with a cholera toxin B subunit-PsaA fusion protein is able to protect mice against colonization with S. pneumoniae but does not significantly alter the natural oral or nasopharyngeal microbiota of mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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