Loss of maternally-derived human herpesvirus-7 immunity and natural infection in Argentinian infants.
| Autor: | Bustos D; Virology Institute Dr J. Vanella, School of Medical Sciences, National University of Córdoba, Córdoba, Argentina., Biganzoli P, Carricart SE, Ferreyra L, Nates SV, Pavan JV |
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| Jazyk: | angličtina |
| Zdroj: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2006 Sep; Vol. 10 (5), pp. 354-7. Date of Electronic Publication: 2006 Jul 20. |
| DOI: | 10.1016/j.ijid.2005.07.005 |
| Abstrakt: | Background: Human herpes virus-7 (HHV-7) infection is widespread throughout the world. No data are available in Argentina about loss of maternally-derived HHV-7 immunity and natural infection. Objectives: The objective of this study was to characterize the time when children lose maternal antibodies and become susceptible to natural infection. Methods: Sera from 39 pregnant women and 207 infants between 2 and 29 months of age were tested. Determination of IgG antibodies was made by indirect immunofluorescence. Results: The seropositive ratio fell in the 2-4 month group (15% seropositive) and increased between 5 months (47% seropositive) and 23 months (67%). Geometric mean titers (GMT) of the infants aged 2-4 months (GMT = 60) were statistically different (p < 0.0001, Student's t-test) to those from the group of pregnant women (GMT = 83) and those from the other infant groups (p < 0.001, least significant difference (LSD) test). The GMT of the groups between 5 and 23 months did not show significant differences whereas those of infants between 24 and 29 months (GMT = 179, 79% seropositive) were different from all the groups studied (p < 0.0001, LSD test). Conclusions: This study shows a significant association between the loss of passive HHV-7 antibody and age. HHV-7 enters the susceptible population at 5 months, leading to the high prevalence of antibodies between 24 and 29 months of age. This study also shows that natural infection by HHV-7 in children during their first years of life follows the infection pattern found in developing countries. |
| Databáze: | MEDLINE |
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