[Tyrosine hydroxylase activity in two-dimensional monomolecular films].

Autor: Eremenko AV, Mineeva MF, Kurochkin IN, Chernov SF, Kuznetsova EA, Val'dman AV
Jazyk: ruština
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1991 Sep; Vol. 112 (9), pp. 246-8.
Abstrakt: The activity of a neurospecific enzyme of tyrosine hydroxylase (TH) in monomolecular films formed onto solid surface was studied. The data obtained show that the formation of two-dimensional films onto negative-charge surfaces by the Langmuir-Schafer technology does not lead to the inactivation of the enzyme. Neuroleptic trifluoperazine increased the activity of TH. Monomolecular films of TH may be used as a sensitive element of biosensors for primary monitoring of neuroleptic-like compounds.
Databáze: MEDLINE