Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements.

Autor: Paget SD; Johnson & Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA., Boggs CM, Foleno BD, Goldschmidt RM, Hlasta DJ, Weidner-Wells MA, Werblood HM, Bush K, Macielag MJ
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Sep 01; Vol. 16 (17), pp. 4537-42. Date of Electronic Publication: 2006 Jun 27.
DOI: 10.1016/j.bmcl.2006.06.023
Abstrakt: A series of pyrrolopyridine-substituted oxazolidinones containing various C-5 acetamide isosteres was synthesized and the structure-antibacterial activity relationships determined against a representative panel of susceptible and resistant Gram-positive bacteria.
Databáze: MEDLINE