| Autor: |
Schimmelpfeng K; Institut für Neurobiologie, Universität Münster, Badestr. 9, 48149 Münster, Germany., Strunk M, Stork T, Klämbt C |
| Jazyk: |
angličtina |
| Zdroj: |
Mechanisms of development [Mech Dev] 2006 Jun; Vol. 123 (6), pp. 487-99. Date of Electronic Publication: 2006 Mar 27. |
| DOI: |
10.1016/j.mod.2006.03.004 |
| Abstrakt: |
Throughout development cell-cell interactions are of pivotal importance. Cells bind to each other or share information via secreted signaling molecules. To a large degree, these processes are modulated by post-translational modifications of membrane proteins. Glycan-chains are frequently added to membrane proteins and assist their exact function at the cell surface. In addition, the glycosylation pathway is required to generate GPI-linkage in the endoplasmatic reticulum. Here, we describe the analysis of the cabrio/mummy gene, which encodes an UDP-N-acetylglucosamine diphosphorylase. This is a well-conserved and central enzyme in the glycosylation pathway. As expected from this central role in glycosylation, cabrio/mummy mutants show many phenotypic traits ranging from CNS fasciculation defects to defects in dorsal closure and eye development. These phenotypes correlate well with specific glycosylation and GPI-anchorage defects in mummy mutants. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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