| Autor: |
da Silva AV; Laboratório de Neurologia Experimental, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. valotta.nexp@epm.br, Martins HH, Marques CM, Yacubian EM, Sakamoto AC, Carrete H Jr, da Silva Centeno R, Stavale JN, Cavalheiro EA |
| Jazyk: |
angličtina |
| Zdroj: |
Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2006 Jun; Vol. 64 (2A), pp. 309-13. Date of Electronic Publication: 2006 Jun 09. |
| DOI: |
10.1590/s0004-282x2006000200026 |
| Abstrakt: |
Epidemiologic studies suggest that neurocysticercosis (NC) is the main cause of symptomatic epilepsy in developing countries. The association between NC and mesial temporal lobe epilepsy (MTLE) has been reported by several authors. Recent data have shown that the presence of NC does not influence the clinical and pathological profile in MTLE patients and suggest that not all cysticercotic lesions are inevitably epileptogenic. We describe a 50-years-old woman with partial seizures due to NC which evolve to MTLE. The patient was submitted to a corticoamygdalohippocampectomy to treat refractory epilepsy. An immunohistochemical study using neuronal markers was made on hippocampal formation. Besides the typical aspects of Ammon's horn sclerosis (AHS), the microscopic examination demonstrates cellular features of hippocampal malformation including dysmorphic neurons and focal bilamination of granular cell layer. We suggest that, in this case, a developmental disorder lowered the threshold for the NC-induced seizures and contributed to the establishment of refractory epilepsy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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