| Autor: |
Carmo JP; Department of Microbiology and Immunology, São Paulo State University (UNESP), Botucatu, SP, Brazil., Dias-Melicio LA, Calvi SA, Peraçoli MT, Soares AM |
| Jazyk: |
angličtina |
| Zdroj: |
Medical mycology [Med Mycol] 2006 Jun; Vol. 44 (4), pp. 363-8. |
| DOI: |
10.1080/13693780500536885 |
| Abstrakt: |
Human monocytes activated by recombinant tumor necrosis factor alpha (TNF-alpha) exhibited significant fungicidal activity on the yeast cells of a highly virulent strain of Paracoccidioides brasiliensis. This process was significantly inhibited in the presence of catalase (CAT - a scavenger of H2O2), but not in the presence of superoxide-dismutase (SOD - a scavenger of superoxide anion) or NG-monomethyl-L-arginine (NG-MMLA - a nitric oxide inhibitor). Furthermore, there was a direct association between the intracellular killing of the fungus and the production of H2O2 by activated cells. These results strongly suggest a role for H2O2 in the killing of highly virulent strains of P. brasiliensis by TNF-alpha-activated human monocytes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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