[The expression of P-glycoprotein in leukemia P388 cells with induced doxorubicin resistance].

Autor: Sukhanov VA, D'iakov VL, Lalaev VV, Iakh'iaev AV, Voronkova IM, Donenko FV, Borovkova NB, Moroz LV
Jazyk: ruština
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1991 Mar; Vol. 111 (3), pp. 290-1.
Abstrakt: beta-D-galactose-containing glycoproteins were prepared from cells P-388 leukemia and from P-388 leukemia cells with induced resistance to doxorubicin. It was shown by HPLC method that plasma membranes from resistant cells contain 4-4.5% P-glycoproteins and plasma membranes from sensitive cells contain P-glycoproteins about 10 times lower.
Databáze: MEDLINE