[Acute-phase reactants and markers of inflammation in venous thromboembolic disease: correlation with clinical and evolution parameters].

Autor:	Marchena Yglesias PJ; Servicio de Medicina Interna, Hospital Virgen de la Luz, Cuenca. pjmy1@yahoo.es, Nieto Rodríguez JA, Serrano Martínez S, Belinchón Moya O, Cortés Carmona A, Díaz de Tuesta A, Bruscas Alijarde MJ, Ruiz Ribó MD
Jazyk:	Spanish; Castilian
Zdroj:	Anales de medicina interna (Madrid, Spain : 1984) [An Med Interna] 2006 Mar; Vol. 23 (3), pp. 105-10.
DOI:	10.4321/s0212-71992006000300002
Abstrakt:	Objective: To asses the association of acute reactants and interleukin 6 and 8 (IL-6 & IL-8) at diagnosis of venous thromboembolic disease (VTD) and clinical outcome. Methods: 100 patients were diagnosed of VTD by image tests. Acute reactants (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen), D-dimer and IL-6 and IL-8 we measured at the moment of diagnosis. We made a 12 month follow-up of these patients to notice any clinical evolution outcomes (recurrences, bleeding, post-phlebitic syndrome, death). Results: IL-6 was increased in 9 patients and IL-8 in 3. The risk factors, time to diagnosis and pulmonary embolism rate were similar in both interleukin groups (normal and high levels). Fibrinogen levels were significantly increased in high IL-6 group (585 +/- 179 vs. 485 +/- 154 mgr/dl; p = 0.05). During follow-up there were 5 deaths, 3 recurrences, 11 bleedings and 43 postphlebitic syndromes. Normal ESR level was associated to postphlebitic syndrome (17.8 +/- 14.5 vs. 31.4 +/- 27.4 mm/1st h; p = 0.016). Patients who had high levels of IL-6 had worse survival than these with normal levels (p = 0.015). Conclusion: IL-6, ESR, and CPR at diagnosis of VTD could be useful to identified patients with higher risks of death and postphlebitic syndrome during the first year after diagnosis.
Databáze:	MEDLINE
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