| Autor: |
Woollen BH; ICI Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK., Hart TB, Batten PL, Laird WJ, Davies DS, Dollery CT |
| Jazyk: |
angličtina |
| Zdroj: |
Human & experimental toxicology [Hum Exp Toxicol] 1991 Jan; Vol. 10 (1), pp. 39-43. |
| DOI: |
10.1177/096032719101000107 |
| Abstrakt: |
1. Fluazifop-butyl, the active ingredient of FUSILADE, a selective herbicide, was administered orally to three male volunteers at a dose level of 0.07 mg kg-1 body weight. Over a period of 6 d between 80 and 93% of the dose was excreted in urine as the metabolite fluazifop, the majority within the first 24 h. Peak plasma concentrations of fluazifop occurred 1-2.5 h after administration. 2. The elimination of fluazifop from plasma and urine can be described by a one-compartment pharmacokinetic model and the elimination half-life was estimated from blood and urine data to be within the range 9-37 h. Fluazifop was found to bind to serum proteins. 3. The study indicates that the amount of fluazifop-butyl absorbed in exposed persons can be assessed by measuring fluazifop concentrations in urine. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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