Isolation and identification of some steroidal glycosides of Furcraea selloa.

4)-beta-D-glucopyranoside chlorogenin (I), 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranoside crestagenin (II) and 3-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranoside gloriogenin (III). Only compound III at 5 micro/ml led to 100% mortality of the S. mansoni (EC50 = 2.25 and 1.91 microg/ml for female and male worm respectively) whereas compounds I and II did not show any activity up to 50 microg/ml. -->
Substance Nomenclature: 0 (Glycosides)
0 (Plant Extracts)
0 (Schistosomicides)
0 (Steroids)
Entry Date(s): Date Created: 20060527 Date Completed: 20060705 Latest Revision: 20220318
Update Code: 20231215
PMID: 16724551
Autor: El-Sayed MM; Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Warrak El-Hadar, Giza, Egypt. sayed_sa@hotmail.com, Abdel-Hameed ES, El-Nahas HA, El-Wakil EA
Jazyk: angličtina
Zdroj: Die Pharmazie [Pharmazie] 2006 May; Vol. 61 (5), pp. 478-82.
Abstrakt: The antischistosomal impact of different extracts of the leaves of Furcraea selloa C. Koch (Family Agavaceae) were screened against adult Schistosoma mansoni worms in vitro using well established culture media. The methanol extract of the plant showed the highest activity as S. mansoni worms recorded 100% mortality at 50 microg/ml after 24 h (EC50 = 29.78 and 29.41 microg/ml for female and male worm respectively). Owing to the high potency of the crude butanolic extract (100% mortality at 20 microg/ ml; EC50 = 10.42 and 8.94 microg/ml for female and male worm respectively) obtained from the methanolic extract, it was submitted to chromatographic separation and isolation using silica gel and Sephadex columns as well as preparative thin layer chromatography. Three steroidal glycosides (saponins) (I-III) were isolated and their structures were elucidated using some spectroscopic and chemical methods. The structure of the three compounds was formulated as 6-O-beta-glucopyranosyl-(1-->4)-beta-D-glucopyranoside chlorogenin (I), 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranoside crestagenin (II) and 3-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranoside gloriogenin (III). Only compound III at 5 micro/ml led to 100% mortality of the S. mansoni (EC50 = 2.25 and 1.91 microg/ml for female and male worm respectively) whereas compounds I and II did not show any activity up to 50 microg/ml.
Databáze: MEDLINE
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