| Autor: |
Teriukova NP, Ivashkina PA, Mirgorodskaia OA, Ivanov VA |
| Jazyk: |
ruština |
| Zdroj: |
Tsitologiia [Tsitologiia] 2005; Vol. 47 (12), pp. 1048-54. |
| Abstrakt: |
By polyacrylamide gel electrophoresis, a phosphoprotein with mol. weight of 42 kDa was detected in non-histone proteins (NHP) of chromatin of Zajdela ascitic hepatoma cells eluted from phosphocellulose with 0.4-0.5 M NaCl. A protein of the same mol. weight is present in narrow fractions of rat kidney chromatin, but is absent in rat liver. It is suggested that the revealed protein corresponds to the tumor-associated heteroorganic NHP antigen detected earlier in NHP chromatin of rat tumor cells. By MALDI mass spectrometry, this phosphoprotein was identified as ERK2/mitogen-activated protein kinase. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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