| Autor: |
Gamaleĭ IA, Kaulin AB, Kirpichnikova KM |
| Jazyk: |
ruština |
| Zdroj: |
Tsitologiia [Tsitologiia] 1991; Vol. 33 (7), pp. 79-85. |
| Abstrakt: |
It has been shown that under the influence of superoxide anion (300 nM) and hydrogen peroxide (100 nM) on murine peritoneal macrophages, the depolarization of membrane takes place, and a change in the rate of fluorescein anion efflux from the cells occurs. Hydrogen peroxide (but not superoxide anions) causes a transient increase in the cytoplasmic Ca2+ concentration. These changes are regarded as early signs of macrophage activation. It is assumed that macrophage activation with reactive oxygen intermediates at such a low concentration might be interpreted as follows: a small portion of stimulated phagocytes activates the whole population with the aid of the products of their own oxidative burst. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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