| Autor: |
Sullebarger JT; Department of Medicine, University of Rochester Medical Center, NY 14642., Fan TH, Torres F, Liang CS |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 1991 Nov 26; Vol. 205 (2), pp. 165-9. |
| DOI: |
10.1016/0014-2999(91)90815-8 |
| Abstrakt: |
To study myocardial beta-adrenoceptor internalization in heart failure, we measured beta-adrenoceptor density in the particulate, light vesicle and supernatant fractions of ventricular tissue of dogs with experimental right ventricular failure and sham-operated dogs. Tissue was fractionated by centrifugation, and beta-adrenoceptors were measured by [125I]iodocyanopindolol binding. Compared to sham-operated controls, beta-adrenoceptors were reduced in all fractions of right ventricular tissue from heart failure animals. Thus, the decreased surface (particulate fraction) receptors observed cannot be explained by internalization alone, and must be associated with altered receptor synthesis or degradation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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