| Autor: |
Zaky DA, Betts RF, Douglas RG Jr, Bengali K, Neil GL |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1975 Mar; Vol. 7 (3), pp. 229-32. |
| DOI: |
10.1128/AAC.7.3.229 |
| Abstrakt: |
The susceptibility of 26 strains of varicella-zoster virus to cytarabine was tested in vitro by measuring reduction in number and size of plaques using human foreskin fibroblast cells. Most strains showed 50% reduction of plaque number by 0.125 mug of cytarabine per ml or less. Cytarabine levels in sera of 12 patients after a single subcutaneous injection of 50 mg/M(2) exceeded this inhibitory level for a period of 75 min. Thus, the subcutaneous route is a potentially useful method of administration of cytarabine for antiviral drug trials. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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