| Autor: |
Kuznetsov VP, Babaiants AA, Frolova IS, Zueva LA, Beliaev DL, Khusainov RM, D'iakonova EV, Vyborov AM, Parfenov VV |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy virusologii [Vopr Virusol] 1991 Jul-Aug; Vol. 36 (4), pp. 300-3. |
| Abstrakt: |
In response to virus induction a culture of donor leukocytes alongside with interferon (IF-alpha) produced a factor of tumor necrosis (TNF). The kinetics of TNF and IF-alpha biosynthesis did not depend on the kind of IF used for priming, was rapid, with maximum production within 7-8 hours. Antibodies to IF-alpha and IF-alpha had no effect on TNF production, while antibody to TNF did not reduce IF-alpha yields. TNF in detectable titres was present in medical preparations of native IF-alpha but was absent in preparations of recombinant IF-alpha and IF-alpha as well as in an injection preparation of IF purified by chemical methods. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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