| Autor: |
Nacher M; CISIH, Cayenne General Hospital, French Guiana. m_nacher@lycos.com, Sarazin F, El Guedj M, Vaz T, Alvarez F, Nasser V, Randrianjohany A, Aznar C, Carme B, Couppié P |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2006 Apr 01; Vol. 41 (4), pp. 468-70. |
| DOI: |
10.1097/01.qai.0000209927.49656.8d |
| Abstrakt: |
To determine whether the initiation of highly active antiretroviral therapy (HAART) had any influence on the incidence of disseminated histoplasmosis, a retrospective cohort study was performed on 1551 patients followed for up to 12 years. After controlling for CD4 counts, age, and sex, patients taking HAART for 2 months or less were more likely to develop disseminated histoplasmosis than untreated patients (respectively, hazard ratio, 3.7 [95% confidence interval, 1.57-8.7]; P = 0.003). In contrast, after 6 months of HAART, treated patients were less likely to develop disseminated histoplasmosis than untreated patients (hazard ratio, 0.6 [95% confidence interval, 0.37-0.98], P = 0.04). This increased incidence suggests that the initiation of HAART and the subsequent immune reconstitution may reveal undiagnosed latent disseminated histoplasmosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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