Polymorphism of the PE domain of PE/PE_PGRS sequences in clinical isolates of Mycobacterium bovis in Mexico.

Autor: Santillan-Flores MA; Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, CENID-Microbiología, Mexico City, Mexico., Flores J, Arriaga-Diaz C, Romero-Torres C, Suárez-Güemes F, Espitia C
Jazyk: angličtina
Zdroj: Veterinary microbiology [Vet Microbiol] 2006 Jul 20; Vol. 115 (4), pp. 364-9. Date of Electronic Publication: 2006 Apr 25.
DOI: 10.1016/j.vetmic.2006.02.021
Abstrakt: Polymorphism of the PE domain of PE/PE_PGRS sequences was studied in Mycobacterium bovis isolates from different Mexican states. Samples were analyzed by spolygotyping and RFLP using IS6110 and a 235-bp fragment of the PE domain of PE/PE_PGRS as probes. With the PE probe, three different genotypes were observed, one being predominant in all states. These results confirm the high conservation of the PE domain and suggests a potential role for PE sequence as a stable genetic marker for bovine tuberculosis.
Databáze: MEDLINE