Increased serum phosphodiesterase activity in women with pre-eclampsia.

Autor: Pinheiro da Costa BE; Programa de Pós-graduação em Medicina e Ciências da Saúde (Nefrologia), Instituto de Pesquisas Biomédicas/Faculdade de Medicina/Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil. bart@pucrs.br, Scocco C, Poli de Figueiredo CE, Guimarães JA
Jazyk: angličtina
Zdroj: BJOG : an international journal of obstetrics and gynaecology [BJOG] 2006 May; Vol. 113 (5), pp. 577-9.
DOI: 10.1111/j.1471-0528.2006.00916.x
Abstrakt: Objective: To measure the activity of serum phosphodiesterase (PDE) in pre-eclampsia.
Design: Case-control study.
Setting: Nephrology Laboratory and Obstetrics Unit at São Lucas Hospital from Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Sample: Twenty-nine normal and 28 pregnant women with pre-eclampsia.
Methods: Serum was collected from women with pre-eclampsia, at the time of diagnosis, and from gestation-matched controls. Circulating PDE activity was assessed by measuring consumption of the substrate thymidine 5'-monophosphate p-nitrophenyl ester and expressed as PDE units/l.
Main Outcome Measures: Serum PDE Activity.
Results: Mean substrate consumption was higher in pre-eclamptic condition (V(max)= 15.8 +/- 1.4 versus 12.7 +/- 0.9 U/L, P= 3.7 x 10(-14)).
Conclusion: These data suggest that altered PDE activity may play a role in pre-eclampsia endothelial dysfunction.
Databáze: MEDLINE
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