| Autor: |
Sidorova MV, Molokoedov AS, Az'muko AA, Aref'eva TI, Melekhov MG, Kukhtina NB, Krasnikova TL, Bespalova ZhD, Bushuev VN |
| Jazyk: |
ruština |
| Zdroj: |
Bioorganicheskaia khimiia [Bioorg Khim] 2006 Mar-Apr; Vol. 32 (2), pp. 161-8. |
| Abstrakt: |
The retro-enantio analogue of peptide 66-77 of the chemokine MCP-1 and two hexapeptide fragments 66-71 and 72-77 of the C-terminal sequence of this protein were synthesized using the Fmoc strategy of solid phase peptide synthesis. The effect of the synthetic peptides upon the MCP-1-stimulated migration of THP-1 mononuclear cells was studied in vitro. The activity of the retro-enantio analogue was found to be comparable with that of the initial peptide 66-77: both peptides inhibit the migration of monocytes and granulocytes into inflammation zones of experimental animals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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