| Abstrakt: |
We investigated 52 incidents of the breast cancer to determine their immunological profile in the different age groups. Breast tissue-specific and at the same time oncologically important immunohistochemical markers: estrogen- and progesterone receptors (ER, PR), oncoprotein HER-2/neu, protein PS2, markers of angiogenesis CD31 and mitotic activity Ki-67 were investigated. Patients were divided into 3 group: I - patients under 45 years (23), II - from 46 to 55 (14), III - 56 year and older (15). Investigations showed that expression of the immunohistochemical markers was dissimilar in the different age groups. In the I group of the estrogen- and progesterone receptors (ER, PR) and protein PS2 was lower, in contrast to the expression of HER-2/neu, CD31 and Ki-67 were higher then in the elder group. Expression of the estrogen- and progesterone receptors (ER, PR) and protein PS2 markers was increasing with the patient age, and significant decrease of the HER-2/neu, CD31 and Ki-67 was observed. This indicates that in younger patients cancer is more aggressive. |
