Late effects risk profiles using the long-term follow-up guidelines in identical twin survivors of acute lymphoblastic leukemia.

Autor: Howell DL; Department of Pediatrics, Emory University, Aflac Cancer and Blood Disorders Service, Children's Healthcare of Atlanta, Atlanta, Georgia 30322, USA. dlhowell1998@msn.com, Lew G, Comeaux LG, Meacham LR
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2007 Sep; Vol. 49 (3), pp. 349-52.
DOI: 10.1002/pbc.20835
Abstrakt: As the number of pediatric cancer survivors increases, the cost of cure (i.e., late effects) needs to be measured through a consistent mechanism. Through the use of the Children's Oncology Group's (COG) Long-Term Follow-Up (LTFU) guidelines, individualized risk profiles can be discerned for each off-therapy patient. These guidelines were used to compare and contrast risk profiles for identical twin females treated for acute lymphoblastic leukemia (ALL). The first twin was treated for high-risk leukemia and the second for standard-risk leukemia, each with different ALL protocols. Timely use of the LTFU guidelines has aided in identifying and treating their adverse late effects.
(Copyright (c) 2006 Wiley-Liss, Inc.)
Databáze: MEDLINE
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