[Microsomal oxidative metabolism in the liver of rats treated with vinorelbine: evaluation through antipyrine elimination].
| Autor: | Montenegro-Alvarez P; Servicio de Farmacia, Hospital Militar Central Gómez-Ulla, Madrid, Spain. pimontenegro@terra.es, González-Alfonso M, Cantarino-Aragón MH, Gutiérrez-Ortega C, Guijarro-Escribano FJ |
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| Jazyk: | Spanish; Castilian |
| Zdroj: | Gastroenterologia y hepatologia [Gastroenterol Hepatol] 2006 Apr; Vol. 29 (4), pp. 224-30. |
| DOI: | 10.1157/13085970 |
| Abstrakt: | Background: Determination of the metabolic efficiency of the liver in neoplastic diseases in patients receiving highly toxic drugs is of great practical importance. Methods: The effect of vinorelbine on the metabolic efficiency of the liver was evaluated by means of phenazone kinetics in rats. The test was compared with a battery of tests routinely used whenever hepatic dysfunction is suspected. Results: Vinorelbine was administered to the rats and the pharmacokinetic parameters of antipyrine were compared with those in control rats. A statistically significant prolongation of the elimination half-life, as well as a decrease in the elimination constant and clearance of antipyrine were found in the rats receiving the anticancer drug in comparison with controls (p < 0.01). Statistically significant correlations were found between the elimination half-life of antipyrine and serum albumin values (p < 0.01) and prothrombin time (p < 0.001). Conclusions: Determination of antipyrine pharmacokinetics allows early detection of vinorelbine-induced hepatic dysfunction, with a sensitive scale. |
| Databáze: | MEDLINE |
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