| Autor: |
Karpova IS, Korets'ka NV, Kochubeĭ TO |
| Jazyk: |
ukrajinština |
| Zdroj: |
Ukrains'kyi biokhimichnyi zhurnal (1999 ) [Ukr Biokhim Zh (1999)] 2005 May-Jun; Vol. 77 (3), pp. 136-41. |
| Abstrakt: |
Using the bacterium B. subtilis as a model and antibiotics as metabolic inhibitors which can suppress replication (mitomycin), transcription (rifampycin) or translation (streptomycin), it is shown that carbohydrate-binding proteins (lectins of plant origin) have different action on intracellular processes under study. The effect depends on lectin's structure and on the condition of bacterial reparation/recombination system. Lectins with chitin-binding domain (STA, WGA) is characterized by the most expressed effect on the repair-proficient strain when the inhibitor of template function of DNA (mitomycin C) was used. The absence of such effect on mutants recP and polC may prove that the corresponding bacterial proteins play the role of mediators in transmission of the signal influence of lectins. The representative of ribosome-inactivating lectins--SNA-I--could increase the streptomycin effect. It is proposed that intracellular effects of lectins have complex mechanisms which need participation of repair functions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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